Quantum Decision: A Survey

人类决策往往体现出非完全理性的特点,这是传统决策科学面临的巨大挑战之一,同时也是量子决策的主要研究对象。量子决策将决策的整个过程描述为认知过程。量子决策认为其背后的数学规律符合量子理论,因此量子决策只是将量子理论作为一种数学工具引入决策科学,其目的在于更好地描述和探索非完全理性这一特性,从而帮助人们更加深刻的认识决策过程,并不是认为大脑的工作过程符合量子理论。同时需要说明的是它并非是一种优化方法。 也就是说,它的初衷并非寻找一个最优策略,而是预测在某种环境下人们最可能做出何种选择。目前量子决策还处于非常稚嫩的阶段,往往用在经济、博弈论和认知科学中,而且应用相对比较简单。

Modeling and Simulation Research on Propagation of Public Opinion

Considering nowadays propagation of Public Opinion possessing different regular pattern and effect, it is the respond of reality demand to research on network ropagation mechanism of public opinion. Simulation is conducted based on network structured by improved scale-free network. Instead of study propagation by single method, the paper analyzes the view exchange process in detail by introducing different degree of individual’s stubbornness and belief degree. Deffaunt Model is used and improved. By studying two kinds of initialization, the paper finds out people will have distinct opinion after propagation in the context of non-intervention, learning the nature of network’s influence in propagation. Furthermore, when intervention is taken into

OCC or PU Learning2.0

OCC or PU Learning Definition: One Class Classification or Positive and Unlabeled Learning corresponds to a special case in machine learning when only a small proportion of positive samples and unlabeled ones are employed for learning task. One frequent task is generally to retrieve positive ones from the unlabeled in the training dataset, namely transductive learning. Detecting positive or identifying negative ones from the unlabeled in both training dataset and unknown is another popular task, also referred to as inductive learning.

Drug Target Protein-Protein Interaction Networks: A Systematic Perspective

The identification and validation of drug targets is crucial in biomedical research. Most recently, lots of studies have been conducted on analyzing drug target features aiming at getting a better understanding on principles of their mechanisms. But most of them are based on either strong biological hypotheses or the chemical and physical properties of those targets separately. In this paper, we examined three main ways to understand the functional biomolecules based on the topological features of drug targets. By comparison between two types of proteins (targets and common proteins) of the protein-protein interactions (PPI) network, the results show there are no significant differences on intermediary and source functions.

Efficient Data Mining Algorithms for Screening Potential Proteins of Drug Targets

The past decades of years has witnessed the booming of pharmacology as well as the dilemma of drug development. Playing in a crucial role in drug design, retrieval of potential proteins of drug targets from open access database is an overwhelming task of challenge but significance, receiving much attention from areas of academia and medical engineering. Human proteins with several measured physical-chemical properties can be well mined for screening reliable candidates, which would accelerate the process of drug development and bring the reduction in expense. In this paper, retrieval of potential drug target proteins (DTPs) from a fine collected dataset was researched from the perspective of data mining. Puzzled with the uncertainty of non-drug target proteins (NDTPs),

A Novel Ensemble Method for Imbalanced Data Learning-Bagging of Extrapolation-SMOTE SVM

One class classification (OCC) problem corresponds to a special case in machine learning area when only a proportion of positive samples and unlabeled ones are employed for learning tasks. Due to the similar characteristics of the learning dataset, we also recognize the positive and learning problems (PU) as equivalent to the OCC problems in this paper. At the same time, some other concepts such as anomaly detection, novelty detection, concept learning show great connection with the OCC when it comes to some specific task. Obviously, the OCC behaves significantly different from the traditional supervised learning paradigm in which the former neg-lects the prior distribution of classes and gets rid of the dependence on the negative

Dynamic Fault detection and Optimization of Assignment for Decision-makers in C2-Organization

The Command and Control (C2) organization plays an indispensable role on planning of military operation. Nowadays the plan oriented more uncertaintybattlefield environment is the hot area. Many studies highlight how to rapidlymake or change the plans with detecting advance information. One of the solutions is based the time-domain metric model to evaluate C2 organizational decision-making capability. We develop an improved simulated annealing algorithm to facilitate this model implementation. In order todiscretize the time-domain, we propose a horizon partition that is based on the task dynamic state.Finally, the optimization

Peeling the Drug Target Proteins Network by a Core Decomposition Method

Currently as the emergence of high throughput technologies for omics data, such as yeast 2 hybrid protein interactions, researches of protein-protein interaction (PPI) had been explosively conducted on. One of the consensuses is that topographical analysis of the intercellular protein interactions lead to new avenues for drug target prediction. In this paper, a panorama view of drug targets is constructed. We found that the connectivity is often not a sufficient criterion to analyze the function of the drug target. On the other hand, the core of the PPI network poses a systematic way to consider the local and global significance of a protein, which indicates the inherent layer structure of the targets interactions.

Drug Targets Properties Analysis and Prediction with Machine Learning

Motivation: Identifying new drug protein plays an important role in pharmaceutical and biomedical research. Before new drug target get manual tested and put into experimental study, a globe filter method is more efficient, practical and economical. New methods are developed to predict new drug targets, but most of them are hypothesis specific or data specific, thus, a more general computational method is required. Result: In this study, we first category the target protein as carrier, transporter, and enzyme, gained 153 overlap proteins among these three categories which should be further analyzed. Using their sequence information we gained their

Drug target proteins prediction with network properties

Motivation: The identification of drug target proteins can certainly benefit new drug development. With the advances in high throughput sequencing technologies, proteins are studied systematically as a network namely protein-protein interaction (PPI) network. PPI plays a fundamental role in many biological processes. Therefore, it provides us a better way to understand drug and protein interaction. In this paper, we analyzed the drug target protein’s interaction network and extracted the physical and chemical properties from protein sequence information. Based both of the network and individual information, the potential drug target proteins are predicted to help identify new drug targets.

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